Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference
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منابع مشابه
Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference.
Many smokers describe the anxiolytic and stress-reducing effects of nicotine, the primary addictive component of tobacco, as a principal motivation for continued drug use. Recent evidence suggests that activation of the stress circuits, including the dynorphin/κ-opioid receptor system, modulates the rewarding effects of addictive drugs. In the present study, we find that nicotine produced dose-...
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The bed nucleus of the stria terminalis (BNST), part of the extended amygdala, has been shown to have an important role in anxiety, stress, and drug withdrawal. Recent research hints that the BNST also modulates appetitive motivation, including drug reinforcement and feeding. However, it remains unclear whether increased chow consumption following intra-BNST opioid microinjection is simply the ...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2019
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.06.071